Transcutaneous induction of stimulus-timing-dependent plasticity in dorsal cochlear nucleus
نویسندگان
چکیده
منابع مشابه
Transcutaneous induction of stimulus-timing-dependent plasticity in dorsal cochlear nucleus
The cochlear nucleus (CN) is the first site of multisensory integration in the ascending auditory pathway. The principal output neurons of the dorsal cochlear nucleus (DCN), fusiform cells, receive somatosensory information relayed by the CN granule cells from the trigeminal and dorsal column pathways. Integration of somatosensory and auditory inputs results in long-term enhancement or suppress...
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Tinnitus and cochlear damage have been associated with changes in somatosensory-auditory integration and plasticity in the dorsal cochlear nucleus (DCN). Recently, we demonstrated in vivo that DCN bimodal plasticity is stimulus timing-dependent, with Hebbian and anti-Hebbian timing rules that reflect in vitro spike timing-dependent plasticity. In this in vivo study, we assessed the stimulus tim...
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Auditory information relayed by auditory nerve fibers and somatosensory information relayed by granule cell parallel fibers converge on the fusiform cells (FCs) of the dorsal cochlear nucleus, the first brain station of the auditory pathway. In vitro, parallel fiber synapses on FCs exhibit spike-timing-dependent plasticity with Hebbian learning rules, partially mediated by the NMDA receptor (NM...
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Multisensory neurons in the dorsal cochlear nucleus (DCN) show long-lasting enhancement or suppression of sound-evoked responses when stimulated with combined somatosensory-auditory stimulation. By varying the intervals between sound and somatosensory stimuli we show for the first time in vivo that DCN bimodal responses are influenced by stimulus-timing dependent plasticity. The timing rules an...
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This study investigates the learning dynamics of cartwheel cells in the dorsal cochlear nucleus (DCN). Cartwheel cells are excited by parallel fibers that carry information from various sources, such as auditory stimuli, proprioception and recurrent inputs from higherorder auditory processing. Thus, these cells are thought to be involved in multimodal sensory integration. Extracellular in vivo ...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2015
ISSN: 1662-5137
DOI: 10.3389/fnsys.2015.00116